Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

J Lv; M Di Biase; RFH Cash; L Cocchi; VL Cropley; P Klauser; Y Tian; J Bayer; L Schmaal; S Cetin-Karayumak; Y Rathi; O Pasternak; C Bousman; C Pantelis; F Calamante; A Zalesky

Journal article

Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

J Lv, M Di Biase, RFH Cash, L Cocchi, VL Cropley, P Klauser, Y Tian, J Bayer, L Schmaal, S Cetin-Karayumak, Y Rathi, O Pasternak, C Bousman, C Pantelis, F Calamante, A Zalesky

Molecular Psychiatry | SPRINGERNATURE | Published : 2021

DOI: 10.1038/s41380-020-00882-5

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Abstract

The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive anatomical maps of structural brain changes associated with the disorder. We aimed to map deviations from normative ranges of brain structure for individual patients and evaluate whether the loci of individual deviations recapitulated group-average brain maps of schizophrenia pathology. For each of 48 white matter tracts and 68 cortical regions, normative percentiles of variation in fractional anisotropy (FA) and cortical thickness (CT) were established using diffusion-weighted and structural MRI from healthy adults (n = 195). Individuals with schizophrenia (n = 322) were classified as either within t..

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University of Melbourne Researchers

Maria Di Biase Author

Robin Cash Author

Vanessa Cropley Author

Paul Klauser Author

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Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation

Funding Acknowledgements

This study used samples and data from the Australian Schizophrenia Research Bank (ASRB), funded by a National Health and Medical Research Council (NHMRC) Enabling Grant (386500; CIs & ASRB Manager: Carr V, Schall U, Scott R, Jablensky A, Mowry B, Michie P, Catts S, Henskens F, Pantelis C, Loughland C), and the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation, and the Schizophrenia Research Institute, using an infrastructure grant from the NSW Ministry of Health. Individual funding support: JL supported by NHMRC Project Grant (ID: APP1142801). MDB (ID: APP1175754) and VC (ID: APP1177370) supported by NHMRC Emerging Leadership Investigator Grants. RC supported by NHMRC Project Grant (ID: APP1103252) and ARC DECRA Fellowship. LC supported by NHMRC Project Grants (ID: APP1099082 and APP1138711). PK supported by Adrian & Simone Frutiger Foundation. OP supported by NIH: R01MH108574. YT supported by NHMRC Project Grant (ID: APP1142801). LS (ID: APP1140764), CP (ID: APP1105825), FC (ID: APP1117724) and AZ (ID: APP1136649) supported by NHMRC Research Fellowships.